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Therapeutic trials in nonalcoholic steatohepatitis: Insulin sensitizers and related methodological issues

✍ Scribed by Vlad Ratziu; Stephen Caldwell; Brent A. Neuschwander-Tetri

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 146 KB
Volume: 52
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.24042

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✦ Synopsis

Insulin sensitizers are attractive candidate therapies for nonalcoholic steatohepatitis mainly because of the strong association between this disease and insulin resistance. This review provides a critical overview of the mechanisms of action, clinical trial results, and safety issues of metformin and glitazones in nonalcoholic steatohepatitis. It also highlights methodological challenges for trial design and proposes endpoints for future proof of principle, registrational, and postmarketing trials.

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