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Therapeutic silencing of an endogenous gene by siRNA cream in an arthritis model mouse

✍ Scribed by Takanashi, M; Oikawa, K; Sudo, K; Tanaka, M; Fujita, K; Ishikawa, A; Nakae, S; Kaspar, R L; Matsuzaki, M; Kudo, M

Book ID
109855323
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
514 KB
Volume
16
Category
Article
ISSN
0969-7128

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## Abstract ## Objective To determine the role of the terminal complement complex (TCC) in the development of experimental antigen‐induced arthritis (AIA) and the therapeutic effects of human anti‐C5 single‐chain Fv (scFv). ## Methods Two different anti‐C5 scFv, one that inhibits both release of