Therapeutic potential of the volatile oil of Nigella sativa seeds in monkey model with experimental shigellosis
✍ Scribed by A. K. Azad Chowdhury; Md. Amirul Islam; Md. Abdur Rashid; Abu Jamil Ferdous
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 68 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0951-418X
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✦ Synopsis
The volatile oil of Nigella sativa seeds was prominent in in vitro anti-shigella activity against eight multiple drug resistant strains of Shigella flexneri. The anti-shigella activity against Shigella flexneri Y SH-4 was observed in the sera of monkeys after 45-60 min of oral administration of the oil. It exhibited promising in vivo anti-shigella activity against the same strain when tested in monkey models with experimental shigellosis, fully curing the infected monkeys within 3 days. The rectal swabs of the experimental groups became free of the challenge organism on day 3 of treatment with the volatile oil.