Therapeutic potential of soluble guanylate cyclase agonists in pulmonary hypertension
โ Scribed by Oleg V Evgenov; Daniel S Kohane; Warren M Zapol
- Publisher
- BioMed Central
- Year
- 2007
- Tongue
- English
- Weight
- 181 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1471-2210
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Lang et al.: The soluble guanylate cyclase stimulator riociguat ameliorates pulmonary hypertension induced by hypoxia and SU5416 in rats. BMC Pharmacology 2011 11(Suppl 1):P43.
Background: Vascular segments in the fetal lung differ anatomically and functionally from one another. At birth, the nitric oxide (NO) pathway plays an integral role in reducing pulmonary vascular resistance through a marked vasodilation. However, the contributions of each vascular segment to this d