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Therapeutic potential of ribbon type oligodeoxynucleotide decoy NF-κB in cardiovascular diseases

✍ Scribed by Mariana K. Osako; Naruya Tomita; Hironori Nakagami; Ryuichi Morishita

Book ID
116985307
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
50 KB
Volume
44
Category
Article
ISSN
0022-2828

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✍ Mariana Kiomy Osako; Naruya Tomita; Hironori Nakagami; Yasuo Kunugiza; Masafumi 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 698 KB

## Abstract ## Background For the development of molecular therapy based on oligodeoxynucleotides (ODN), ODN have to be stable against nucleases and be specific to the target transcription factor. To decrease non‐specific binding and degradation from the 3′‐terminus of ODN, we designed partially a