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Therapeutic factors secreted by mesenchymal stromal cells and tissue repair

✍ Scribed by Ryang Hwa Lee; Joo Youn Oh; Hosoon Choi; Nikolay Bazhanov

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
278 KB
Volume
112
Category
Article
ISSN
0730-2312

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✦ Synopsis

Abstract

Systemic administration of MSCs resulted in remarkable functional improvements in injured tissues without either long‐term engraftment or differentiation in many clinical and experimental situations. Emerging evidence suggest that most of the beneficial effects of MSCs could be explained by secretion of soluble factors that have multiple effects including modulation of inflammatory and immune reactions, protection from cell death, and stimulation of endogenous progenitor cells. In this review, we focus on the therapeutic factors that account for the beneficial effects of MSCs in animal models of human diseases. J. Cell. Biochem. 112: 3073–3078, 2011. © 2011 Wiley Periodicals, Inc.

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