Therapeutic efficacy of HI-6 in soman-poisoned marmoset monkeys
β Scribed by Herman P.M. van Helden; Herma J. van der Wiel; Jan de Lange; Ruud W. Busker; Bert P.C. Melchers; Otto L. Wolthuis
- Book ID
- 113207863
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 748 KB
- Volume
- 115
- Category
- Article
- ISSN
- 0041-008X
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The bispyridinium oxime HI-6, 1-((((4-amino-carbonyl)pyridinio)methoxy) methyl)-2-(hydroxyimino)methyl)pyridinium dichloride monohydrate, combined with atropine is an effective treatment for soman (pinacolyl methylphosphonofluoridate) poisoning but is relatively ineffective against tabun (ethyl N-di
Investigations into the therapeutic properties of various combinations of the bispyridinium salts HS-3 and HS-6 and the cholinolytics atropine and benactyzine against soman poisoning in unanesthetized male beagles were performed. In our investigations we observed that: 1. The most effective protecti