Therapeutic Efficacy of 2-Methoxyestradiol Microcrystals Encapsulated within Polyelectrolyte Multilayers
✍ Scribed by Su He Wang; Xiangyang Shi; Xisui Chen; James R. Baker Jr.
- Book ID
- 102933814
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 531 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1616-5187
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✦ Synopsis
Abstract
Development of a novel formulation of anticancer drugs to improve their water‐solubility and bioavailability remains a great challenge. Herein, the potential anticancer agent 2‐methoxyestradiol (2‐ME) was selected as a model drug and was encapsulated within polyelectrolyte (PE) multilayers by layer‐by‐layer deposition of oppositely charged PEs onto the drug microcrystal surfaces. Cell viability and morphology observation of two cell lines reveal that the PE multilayer‐encapsulated 2‐ME microcrystals markedly decrease the cell viability, displaying similar inhibitory effect to that of the conventional formulation of 2‐ME dissolved in ethanol. The current approach to encapsulate hydrophobic drug microparticles may be useful for formulating different drugs for a variety of biological applications.
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