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Therapeutic effects of some cholinolytics in organophosphate intoxications

โœ Scribed by J. Faff; G. Borkowska; W. Bak

Publisher
Springer-Verlag
Year
1976
Tongue
English
Weight
377 KB
Volume
36
Category
Article
ISSN
0340-5761

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โœฆ Synopsis

The therapeutic effects of pipethanate (sycotrol) and two newly synthetized cholinolytics, DPX-8 and ANC-51, were compared with atropine in mice poisoned by DDVP, fluostigmine, phospholine, and paraoxon. The antagonistic activity of tested drugs against acetylcholine-induced contraction of rat ileum and oxotremorine-induced salivation and tremor in the mouse was also studied. The anticholinergic activity of pipethanate, DPX-8, and ANC-51 was weaker than that of atropine. However, the therapeutic effect of pipethanate was higher than that of atropine in mice poisoned by the organophosphates. DPX-8 and ANC-51 afforded a better antidotal effect than atropine only in DDVPpoisoned mice.

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