Therapeutic effect of low-dose IL-18 combined with IL-10 on collagen-induced arthritis by down-regulation of inflammatory and Th1 responses and induction of Th2 responses

Therapeutic effect of urocortin on colla

Therapeutic effect of urocortin on collagen-induced arthritis by down-regulation of inflammatory and Th1 responses and induction of regulatory T cells

✍ Elena Gonzalez-Rey; Alejo Chorny; Nieves Varela; Francisco O'Valle; Mario Delgad 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 767 KB

## Abstract ## Objective To investigate the potential therapeutic action of the immunomodulatory neuropeptide urocortin (UCN) in an experimental model of rheumatoid arthritis (RA). ## Methods After disease onset, DBA/1J mice with collagen‐induced arthritis (CIA) were treated with UCN, and the in