Therapeutic antibody gene transfer
β Scribed by Marasco, Wayne A
- Book ID
- 109903198
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 95 KB
- Volume
- 23
- Category
- Article
- ISSN
- 1087-0156
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## Abstract ## Background One of the drawbacks of the currently available vectors for gene therapy is the lack of selectivity in gene delivery. We have therefore investigated a strategy to generate immunoliposomes to target nonβviral vectors to cell surface receptors on endothelium. ## Materials
The liver represents a model organ for gene therapy. A method has been developed for hepatic gene transfer in vivo by the direct infusion of recombinant retroviral vectors into the portal vasculature, which results in the persistent expression of exogenous genes. To determine if these technologies a