Therapeutic activity of agonistic monoclonal antibodies against CD40 in a chronic autoimmune inflammatory process

Frequent enrichment for CD8 T cells reac

Frequent enrichment for CD8 T cells reactive against common herpes viruses in chronic inflammatory lesions: towards a reassessment of the physiopathological significance of T cell clonal expansions found in autoimmune inflammatory processes

✍ Emmanuel Scotet; Marie-Alix Peyrat; Xavier Saulquin; Christelle Retiere; Christe 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 149 KB 👁 2 views

We recently evidenced a dramatic enrichment for T cells reactive against Epstein-Barr virus (EBV) within inflamed joints of two rheumatoid arthritis patients. To assess the generality of this phenomenon and its relevance to autoimmunity, we studied the responses of CD8 T cells from patients with eit