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Theory of protein secondary structure and algorithm of its prediction

✍ Scribed by O. B. Ptitsyn; A. V. Finkelstein

Publisher
Wiley (John Wiley & Sons)
Year
1983
Tongue
English
Weight
606 KB
Volume
22
Category
Article
ISSN
0006-3525

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✦ Synopsis

Synopsis

A molecular theory of protein secondary structure is presented that takes account of both local interactions inside each chain region and long-range interactions between different regions, incorporating all these interactions in a single Ising-like model. Local interactions are evaluated from the stereochemical theory describing the relative stabilities of aand b-structures for different residues in synthetic polypeptides, while long-range effects are approximated by the interaction of each chain region with the ave&ed hydrophobic template. Based on this theory, an algorithm of protein secondary structure prediction is proposed and examples are given of "blind" predictions made before the x-ray structural data became available.

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