๐”– Bobbio Scriptorium
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Theory of inactivation and reactivation of transforming DNA

โœ Scribed by S. E. Bresler; V. L. Kalinin; D. A. Perumov

Publisher
Wiley (John Wiley & Sons)
Year
1964
Tongue
English
Weight
554 KB
Volume
2
Category
Article
ISSN
0006-3525

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โœฆ Synopsis

A simple quantitative theory of inactivation of transforming DNA has been formulated. It is based on the idea that genetic recombination of the molecule of transforming DNA with the bacterial genome is possible only from the point mutation of the gene up to the nearest hit or point of damage on the corresponding DNA molecule. Our data and the data of other authors on the kinetics of inactivation by HNOz or U.V. light or both are consistent with these theoretical predictions. Theoretical predictions were made concerning the extent of reactivation by fusion and annealing of damaged DNA with a diluting genetically inactive DNA. These estimates have been reasonably confirmed by our experimental results.

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