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Theoretical Study of the RNA Hydrolysis Mechanism of the Dinuclear Zinc Enzyme RNase Z

✍ Scribed by Rong-Zhen Liao; Fahmi Himo; Jian-Guo Yu; Ruo-Zhuang Liu

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
730 KB
Volume
2009
Category
Article
ISSN
1434-1948

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πŸ“œ SIMILAR VOLUMES

Theoretical Investigation of the Reactio
Theoretical Investigation of the Reaction Mechanism of the Dinuclear Zinc Enzyme Dihydroorotase
✍ Rong-Zhen Liao; Jian-Guo Yu; Frankβ€…M. Raushel; Fahmi Himo πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 484 KB

## Abstract The reaction mechanism of the dinuclear zinc enzyme dihydroorotase was investigated by using hybrid density functional theory. This enzyme catalyzes the reversible interconversion of dihydroorotate and carbamoyl aspartate. Two reaction mechanisms in which the important active site resid