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Theoretical Study of Electron Transfer between the Photolyase Catalytic Cofactor FADH - and DNA Thymine Dimer

✍ Scribed by Antony, Jens; Medvedev, Dmitry M.; Stuchebrukhov, Alexei A.


Book ID
121306985
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
244 KB
Volume
122
Category
Article
ISSN
0002-7863

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Theoretical Study of Electron Transfer b
✍ Antony, Jens; Medvedev, Dmitry M.; Stuchebrukhov, Alexei A. πŸ“‚ Article πŸ“… 2000 πŸ› American Chemical Society 🌐 English βš– 244 KB

Photolyase is an enzyme that catalyzes photorepair of thymine dimers in UV damaged DNA by electron-transfer reaction. We docked a thymine dimer to photolyase catalytic site, using crystal structure coordinates of the substrate-free enzyme from Escherichia coli, studied molecular dynamics of the syst