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Theoretical Study of Amine-Assisted Aminolysis of Penicillins − The Kinetic Role of the Carboxylate Group

✍ Scribed by Natalia Díaz; Dimas Suárez; Tomás L. Sordo


Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
490 KB
Volume
2001
Category
Article
ISSN
1434-193X

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Theoretical Study of Ammonolysis of Mono
✍ Natalia Díaz; Dimas Suárez; Tomás L. Sordo 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 German ⚖ 495 KB

The ammonolysis reaction of 3-(formylamino)-4-methyl-2-oxoazetidine-1-sulfonate is investigated by quantum-chemical methods (B3LYP/6-31 G\*) as a model system of the aminolysis reaction of monobactam antibiotics involved in the allergic reaction to these drugs. The influence of the N-sulfonate group