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Theoretical studies of the activation mechanism of histamine H2-receptors: Dimaprit and the receptor model

โœ Scribed by Leonardo Pardo; Aleksander P. Mazurek; Roman Osman; Harel Weinstein


Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
485 KB
Volume
36
Category
Article
ISSN
0020-7608

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A pharmacophore model for histamine H3 ligands is derived that reveals the putative interaction of both H3 agonists and antagonists with an aspartate residue of the receptor. This interaction is determined by applying the density functional theory implemented in a program package adapted for paralle