𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Theoretical studies of drug receptor interaction

✍ Scribed by Warshel, A


Book ID
123352703
Publisher
Elsevier Science
Year
1976
Tongue
English
Weight
386 KB
Volume
1
Category
Article
ISSN
0968-0004

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## Abstract Bicyclams inhibit HIV replication by binding to the CXCR4 chemokine receptor, which is the main coreceptor for gp120 used by X4, T‐tropic strains of HIV for membrane fusion and cell entry. Bicyclam AMD3100 mainly interacts with the aspartic acid residues namely Asp171 and Asp262, which