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Theoretical investigation of the catalytic mechanism of the protein arginine deiminase 4 enzyme

✍ Scribed by M. Leopoldini; T. Marino; M. Toscano


Book ID
105886211
Publisher
Springer
Year
2008
Tongue
English
Weight
366 KB
Volume
120
Category
Article
ISSN
1432-2234

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## Abstract The reaction mechanism of the dinuclear zinc enzyme dihydroorotase was investigated by using hybrid density functional theory. This enzyme catalyzes the reversible interconversion of dihydroorotate and carbamoyl aspartate. Two reaction mechanisms in which the important active site resid