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Theoretical insights into the catalytic mechanism of β-hexosaminidase

✍ Scribed by Óscar Passos; Pedro Alexandrino Fernandes; Maria João Ramos


Book ID
105886647
Publisher
Springer
Year
2011
Tongue
English
Weight
523 KB
Volume
129
Category
Article
ISSN
1432-2234

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Theoretical insights into the mechanism
✍ T. K. Manojkumar; Chunzhi Cui; Kwang S. Kim 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 192 KB 👁 1 views

## Abstract Acylation of acetylcholine (ACh) catalyzed by acetylcholinesterase (AChE) has been studied using high‐level theoretical calculations on a model system that mimics the reaction center of the enzyme, and compared with uncatalyzed acylation reaction. The geometries of all the intermediates