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Theoretical Considerations of Cross-immunity, Recombination and the Evolution of New Parasitic Strains

✍ Scribed by Mark M. Tanaka; Marcus W. Feldman

Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
240 KB
Volume
198
Category
Article
ISSN
0022-5193

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✦ Synopsis

We explore the dynamics of multiple strains of a parasite in order to assess the conditions under which a novel strain, perhaps a mutant or migrant, may invade a population that already carries an endemic strain. Multiple strain dynamics can be modeled through coinfection, superinfection or complete cross-immunity. We examine these three modes to discuss the relationships among cross-immunity, the basic reproductive rates of each strain, and the invasion of the new strain. Superinfection is more restrictive than coinfection in the proportion of parameters that allows invasion. The coinfection model is extended to allow haploid strains to undergo recombination within the host. We investigate the effects of recombination and cross-immunity on the invasion of new strains. Interestingly, although recombination is understood to generate diversity, it is not always advantageous.

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