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Theoretical conformational analysis of poly(val-pro-gly-gly) withcispeptide bond at val-pro portion

✍ Scribed by Masahito Oka; Yoshihiro Baba; Akihiro Kagemoto; Akio Nakajima


Book ID
104729550
Publisher
Springer
Year
1991
Tongue
English
Weight
465 KB
Volume
25
Category
Article
ISSN
0170-0839

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The synthesis and analysis of the confor
✍ Bredenkamp, Martin W. ;Holzapfel, Cedric W. ;van Zyl, Wynand J. πŸ“‚ Article πŸ“… 1990 πŸ› John Wiley and Sons 🌐 English βš– 525 KB

## Abstract The cyclic peptide cyclo[‐L‐Pro‐L‐Leu‐D‐(Gln)Thz‐(Gly)Thz‐L‐Val‐] (1a), which is a diastereomer of the antineoplastic agent dolastatin 3 (1b), and contains the unusual thiazole amino acids, was synthesized. All the peptide bonds of the cyclic peptide 1a are __trans__ in solution, and th