Theoretical chemistry studies on the catalytic mechanism of liver alcohol dehydrogenase
β Scribed by O. Tapia
- Publisher
- Elsevier Science
- Year
- 1988
- Weight
- 779 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0304-5102
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## Abstract Semiempirical (AM1) molecular orbital theory has been used to investigate the oxidation of alcohols at the active site of liver alcohol dehydrogenase (LADH). The model active site consists of a zinc dication coordinated to two methylβmercaptans (Cysβ46, Cysβ176), an imidazole (Hisβ67),
## Abstract BACKGROUND: [bmim][PF~6~] is a hydrophobic ionic liquid which could be considered as an environmentally friendly solvent for biocatalysis. In pure [bmim][PF~6~], however, alcohol dehydrogenase from yeast (YADH) has no catalytic activity. The aim of the present work was (1) to quantitati