𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Theoretical calculations of β-lactam antibiotics

✍ Scribed by J. Frau; J. Donoso; B. Vilanova; F. Muñoz; F. García Blanco


Publisher
Springer
Year
1993
Tongue
English
Weight
597 KB
Volume
86
Category
Article
ISSN
1432-2234

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Theoretical Calculations of β-Lactam Ant
✍ Juan Frau; Josefa Donoso; Francisco Muñoz; Francisco García Blanco 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 German ⚖ 989 KB

The gas-phase basic hydrolysis of clavulanic acid (a) was studied by using the AM1 semi-empirical method. The results obtained show that the hydroxyethylidene side chain at C(2) is pivotal to the stability of the different reaction products involved. The products with an open oxazolidine ring are mo

Theoretical Calculations of β-Lactam Ant
✍ Juan Frau; Josefa Donoso; Francisco Muñoz; Francisco Gracia-Blanco 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 German ⚖ 571 KB

We used semi-empirical and ab initio calculations to investigate the nucleophilic attack of the OHion on the 8-lactam carbonyl group. Both allowed us to detect reaction intermediates pertaining to proton-transfer reactions rather than the studied reaction. We also used the PM3 semi-empirical method

Theoretical calculations of β-lactam ant
✍ J. Frau; J. Donoso; F. Muñoz; F. García Blanco 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 905 KB

Semiempirical AM1, MINDO/3, and MNDO methods have been used in the study of the alkaline hydrolysis of P-lactam antibiotics through a base-catalyzed, acyl-cleavage, bimolecular mechanism. In this work, the hydroxyl ion has been chosen as nucleophilic agent and the azetidin-2-one ring like a model of

Theoretical calculations of β-lactam ant
✍ J. Frau; J. Donoso; F. Muñoz; F. García Blanco 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 697 KB

A comprehensive study on the gas-phase alkaline hydrolysis of cephalosporins by using the semiempirical AM1 method was carried out. Cephalothin was the model compound used on account of the presence of a good leaving group at C(3'). According to the results obtained, the hydrolysis process takes pla

Monocyclic β-lactam antibiotics
✍ Christopher M. Cimarusti; Richard B. Sykes 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 958 KB

reevaluation of beta-lactam bond deformation as a criterion for a penicillin-like mode-of-action. ## 11. MECHANISM OF ACTION The mechanism of action of the naturally-occurring monobactams was examined at an early They were shown to interact with certain of the penicillin-binding proteins (PBP's) o