𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Theoretical Calculation and Prediction of Caco-2 Cell Permeability Using MolSurf Parametrization and PLS Statistics

✍ Scribed by Ulf Norinder; Thomas Österberg; Per Artursson


Book ID
110309311
Publisher
Springer US
Year
1997
Tongue
English
Weight
495 KB
Volume
14
Category
Article
ISSN
0724-8741

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Theoretical calculation and prediction o
✍ Ulf Norinder; Thomas Österberg 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 187 KB

A method of modeling and predicting drug transport processes using simple, theoretically computed molecular descriptors and multivariate statistics has been investigated in four data sets related to Caco-2 cell permeability, human intestinal absorption, brain±blood partitioning, and immobilized arti

Estimation of ADME properties in drug di
✍ Juan A. Castillo-Garit; Yovani Marrero-Ponce; Francisco Torrens; Ramón García-Do 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 276 KB

The in vitro determination of the permeability through cultured Caco-2 cells is the most often-used in vitro model for drug absorption. In this report, we use the largest data set of measured P(Caco-2), consisting of 157 structurally diverse compounds. Linear discriminant analysis (LDA) was used to