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Theoretical and experimental evaluation of continuous arterial spin labeling techniques

✍ Scribed by Rolf Pohmann; Juliane Budde; Edward J. Auerbach; Gregor Adriany; Kâmil Uğurbil

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
468 KB
Volume
63
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

Continuous arterial spin labeling is known to be the most sensitive arterial spin labeling technique. To avoid magnetization transfer effects and to overcome hardware limitations, several sequences have been proposed that adiabatically label the inflowing blood. Four of these methods are examined with respect to their sensitivity both theoretically by Bloch equation simulations and experimentally. All sequences were optimized carefully by adjusting their measurement parameters based exclusively on the results of simulations. Perfusion measurements on the human brain obtained at 3 T result in excellent images from all techniques, while differences in sensitivity are similar to those expected from the simulations. Magn Reson Med, 2010. © 2009 Wiley‐Liss, Inc.

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