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Theoretical analysis of mutation hotspots and their DNA sequence context specificity

โœ Scribed by Igor B. Rogozin; Youri I. Pavlov


Book ID
117768154
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
251 KB
Volume
544
Category
Article
ISSN
1383-5742

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The sequences of a collection of 261 spontaneous lacI- mutants recovered in a PolA- strain of Escherichia coli have indicated an increase in the frequency of most classes of mutation in this strain. Among base substitutions in lacI, a preference for transversions over transitions was observed. In ad