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Theophylline molecularly imprinted polymer dissociation kinetics: a novel sustained release drug dosage mechanism

✍ Scribed by Mikael C. Norell; Håkan S. Andersson; Ian A. Nicholls

Book ID: 101286073
Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 77 KB
Volume: 11
Category: Article
ISSN: 0952-3499
DOI: 10.1002/(sici)1099-1352(199812)11:1/6<98::aid-jmr399>3.0.co;2-y

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✦ Synopsis

The template release kinetics of theophylline molecularly imprinted polymers has been examined with a view to determining their potential as a controlled release drug dosage form. The basis for the ligand selectivity of these polymers has been shown through the demonstration of pre-polymerization templatemonomer complexation and HPLC studies of the product polymer ligand selectivities. The release kinetics shows a dependence upon template loading and pH. Small differences in release characteristics between imprinted and non-imprinted (reference) polymers have been observed.