TheLRRK2G2019S mutation as the cause of Parkinson’s disease in Ashkenazi Jews
✍ Scribed by Avner Thaler; Elissa Ash; Ziv Gan-Or; Avi Orr-Urtreger; Nir Giladi
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 218 KB
- Volume
- 116
- Category
- Article
- ISSN
- 1435-1463
No coin nor oath required. For personal study only.
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## Abstract Among mutations associated with autosomal dominant and sporadic Parkinson's disease (PD) the G2019S substitution in the leucine‐rich repeat kinase 2 (LRRK2) gene is the most frequently identified. To estimate its frequency in Russia, we analyzed 208 patients with PD from the Northwester
To evaluate the frequency of the LRRK2 G2019S mutation in Italy, we tested 1,072 probands with Parkinson's disease (PD; 822 sporadic and 250 familial): 20 patients (1.9%) carried the G2019S mutation, 11 patients (1.3%) were sporadic, and 9 (4.3%) had a positive family history. Considering only proba