TheKras2oncogene and mouse lung carcinogenesis
β Scribed by Gang-Hong Lee
- Book ID
- 106239045
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 261 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0918-4287
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## Abstract The __Nkx2.1__ homeobox gene and transforming growth factorβΞ²1 (TGFβΞ²1) are essential for organogenesis and differentiation of the mouse lung. NKX2.1 is a marker of human lung carcinomas, but it is not known whether this gene participates in early tumorigenesis. Addition of TGFβΞ²1 to TG
Transforming growth factor-beta (TGF-beta) is a growth modulator that inhibits the proliferation of many epithelial cells through interaction with its receptors, the type I and type II receptors (TGF-beta RI and RII) by activating their serine/threonine kinase activities. Loss of growth inhibition b