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TheFgfr2W290Rmouse model of Crouzon syndrome

✍ Scribed by Gong, S.-G.


Book ID
118783185
Publisher
Springer
Year
2012
Tongue
English
Weight
631 KB
Volume
28
Category
Article
ISSN
0256-7040

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Crouzon syndrome, one of the best known of many craniofacial syndromes, is an autosomal dominant disorder characterized by craniosynostosis, prominent eyes, and midfacial hypoplasia due to abnormal development and premature fusion of the skull. Recently mutations in the fibroblast growth factor rece

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## Abstract Crouzon syndrome is an autosomal‐dominant disorder that causes premature fusion of the cranial suture. Crouzon, Pfeiffer, and Apert syndromes are caused by mutations in the extracellular, third immunoglobulin‐like domain, and adjacent linker regions (exons IIIa and IIIc) of the fibrobla