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TheC1473Gpolymorphism in genetph2is the main factor mediating the genetically defined variability of tryptophan hydroxylase-2 activity in the mouse brain

✍ Scribed by A. V. Kulikov; D. V. Osipova; N. K. Popova

Book ID
110199463
Publisher
SP MAIK Nauka/Interperiodica
Year
2007
Tongue
English
Weight
187 KB
Volume
43
Category
Article
ISSN
1022-7954

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## Abstract Tryptophan hydroxylase‐2 (TPH2) is the rate‐limiting enzyme of brain serotonin synthesis. The C1473G polymorphism in the mouse tryptophan hydroxylase‐2 gene affects the enzyme's activity. In the present study, we investigated the linkage between the C1473G polymorphism, enzyme activity