A strong association has been described in cross-sectional studies between the ~4 allele of the apolipoprotein E and late-onset Alzheimer's disease (LOAD). This study addresses the relationship between disease progression and the ~4 allele in 6 2 sporadic LOAD (onset at age 70 and over) patients. Di
✦ LIBER ✦
TheArg194Trppolymorphism in DNA repair gene XRCC1 and the risk for sporadic late-onset Alzheimer's disease
✍ Scribed by S. Doğru-Abbasoğlu; G. Aykaç-Toker; H. A. Hanagasi; H. Gürvit; M. Emre; M. Uysal
- Publisher
- Springer Milan
- Year
- 2007
- Tongue
- English
- Weight
- 55 KB
- Volume
- 28
- Category
- Article
- ISSN
- 1590-1874
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## Abstract Linkage studies have suggested a susceptibility locus for late‐onset Alzheimer's disease (LOAD) on chromosome 21. A functional candidate gene in this region is the β‐amyloid precursor protein (APP) gene. Previously, coding mutations in APP have been associated with early onset Alzheimer