The Δ32 deletion of CCR5 receptor in rheumatoid arthritis
✍ Scribed by Steven P. Cooke; Graham Forrest; Patrick J. W. Venables; Ali Hajeer
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 373 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0004-3591
No coin nor oath required. For personal study only.
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The 32 nucleotide deletion in the CCR-5 chemokine receptor gene referred to as ⌬ccr-5 has been shown to confer resistance to HIV-1. Using PCR, 1,105 human subjects and 33 common chimpanzees were genotyped attributing them to one of the three possible genotypes: wild-type homozygote (w/w); ⌬ccr-5 hom
Objective. To study the role of the chemokine receptors CCR5 and CCR2 in patients with arthritis. Methods. CCR5 expression on peripheral blood leukocytes was compared with the expression on leukocytes isolated from the synovial fluid of 20 patients with different rheumatic joint diseases. Three add