The δ agent: HBsAg particles with δ antigen and RNA in the serum of an HBV carrier
✍ Scribed by Ferruccio Bonino; Bill Hoyer; Eugenie Ford; J. Wai-Kuo Shih; Robert H. Purcell; Dr. John L. Gerin
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- English
- Weight
- 497 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0270-9139
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✦ Synopsis
The hepatitis B virus-associated delta antigen was detected in the serum of a young female drug addict with acute hepatitis and a previous history of hepatitis B surface antigen carrier. Delta antigen was associated with a 35to 37-nm subpopulation of hepatitis B surface antigen particles which banded at a density of 1.25 g m per cm3 of CsCl and contained a small RNA of approximately 5.5 x 10' molecular weight. This report demonstrates that delta antigen is associated with a unique subpopulation of hepatitis B surface antigen particles and small RNA in human serum.
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Characteristic cytoplasmic membranous structures and intranuclear aggregates of particles similar to those reported in non-A, non-B hepatitis were observed by electron microscopy in the liver biopsies of chimpanzees inoculated with human serum, infectious for the delta agent. The ultrastructural cha