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The β7−β8 Loop of the p51 Subunit in the Heterodimeric (p66/p51) Human Immunodeficiency Virus Type 1 Reverse Transcriptase Is Essential for the Catalytic Function of the p66 Subunit †

✍ Scribed by Pandey, Pradeep K.; Kaushik, Neerja; Talele, Tanaji T.; Yadav, Prem N. S.; Pandey, Virendra N.

Book ID: 127149985
Publisher: American Chemical Society
Year: 2001
Tongue: English
Weight: 373 KB
Volume: 40
Category: Article
ISSN: 0006-2960
DOI: 10.1021/bi002872j

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## Abstract The human immunodeficiency virus type 1 reverse transcriptase (HIV‐1 RT) is a heterodimeric enzyme composed of p66 and p51 subunits. Earlier, we showed that the β7–β8 loop of p51 is crucial for polymerase activity of HIV‐1 RT as either deletion or Ala substitution of amino acids in the