The α7 nicotinic acetylcholine receptor subtype mediates nicotine protection against NMDA excitotoxicity in primary hippocampal cultures through a Ca2+ dependent mechanism

Tobacco cembranoids protect the function

Tobacco cembranoids protect the function of acute hippocampal slices against NMDA by a mechanism mediated by α4β2 nicotinic receptors

✍ P.A. Ferchmin; Jiukuan Hao; Dinely Perez; Mario Penzo; Hector M. Maldonado; Mari 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 431 KB

## Abstract Nicotine has been reported to be neuroprotective in experimental and epidemiological studies. In addition to nicotine, tobacco and cigarette smoke contain cembranoids, which are antagonists of neuronal nicotinic receptors (nAChR). Exposure of hippocampal slices to __N__‐methyl‐D‐asparta