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The α2-adrenoceptor antagonist Org 3770 enhances serotonin transmission in vivo

✍ Scribed by Thijs De Boer; Frans Nefkens; Ad Van Helvoirt


Book ID
115889999
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
189 KB
Volume
253
Category
Article
ISSN
0014-2999

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Org 3770 (mirtazapine, RemeronB) is an antidepressant with an atypical behavioural pharmacology. Org 3770 was found inactive in classical tests used to detect antidepressants, but showed antidepressant-like effects on REM sleep, in the DRL-72 (measuring impulse control) and in the (subchronic) bulbe