Recent interest has focused on the largest pedigree reported to date with histologically proven Lewy body parkinsonism with an autosomal-dominant mode of transmission.' It consisted of descendants of several immigrants to the United States linked to collateral Italian descendants by a common ancesto
The α-synuclein gene is not a major risk factor in familial Parkinson disease
✍ Scribed by W. K. Scott; L. H. Yamaoka; J. M. Stajich; B. L. Scott; J. M. Vance; A. D. Roses; M. A. Pericak-Vance; R. L. Watts; M. Nance; J. Hubble; W. Koller; M. B. Stern; A. Colcher; F. H. Allen Jr; B. C. Hiner; J. Jankovic; W. Ondo; N. G. Laing; F. Mastaglia; C. Goetz; E. Pappert; G. W. Small; D. Masterman; J. L. Haines; T. L. Davies; A. D. Roses
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 48 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1364-6745
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## Abstract α‐Synuclein is one of the main components of Lewy bodies, a pathological marker of Parkinson's disease (PD). Certain missense mutations of the α‐synuclein gene cause familial PD, but the role of the gene in sporadic PD is still controversial. We scrutinized polymorphisms of the α‐synucl