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The α-L-Threofuranosyl-(3′→2′)-oligonucleotide System (‘TNA'): Synthesis and Pairing Properties

✍ Scribed by Kai-Uwe Schöning; Peter Scholz; Xiaolin Wu; Sreenivasulu Guntha; Guillermo Delgado; Ramanarayanan Krishnamurthy; Albert Eschenmoser

Publisher
John Wiley and Sons
Year
2002
Tongue
German
Weight
502 KB
Volume
85
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Our studies of α‐L‐Threofuranosyl‐(3′→2′)‐oligonucleotides (‘TNA') are part of a systematic experimental inquiry into the base‐pairing properties of potentially natural nucleic acid alternatives taken from RNA's close structural neighborhood. TNA is an efficient Watson‐Crick base‐pairing system and has the capability of informational cross‐pairing with both RNA and DNA. This property, together with the system's constitutional and (presumed) generational simplicity, warrants special scrutiny of TNA in the context of the search for chemical clues to RNA's origin.

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