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The α-ketoglutarate dehydrogenase complex in neurodegeneration

✍ Scribed by Gary E Gibson; Larry C.H Park; Kwan-Fu Rex Sheu; John P Blass; Noel Y Calingasan

Book ID
117410511
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
273 KB
Volume
36
Category
Article
ISSN
0197-0186

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We report an immunohistochemical study of the mitochondrial a-ketoglutdrdte dehydrogenase complex (KGDHC) in the substantia nigra in Parkinson's disease. The KGDHC, the three enzyme complex catalyzing the oxidation of a-ketoglutarate to succinate through succinic semialdehyde, is the rate-regulating