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The α-factor mating pheromone of Saccharomyces cerevisiae: a model for studying the interaction of peptide hormones and G protein-coupled receptors

✍ Scribed by Fred Naider; Jeffrey M. Becker


Book ID
116830333
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
467 KB
Volume
25
Category
Article
ISSN
0196-9781

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Peptides representing both loop and the sixth transmembrane regions of the ␣-factor receptor of Saccharomyces cerevisiae were synthesized by solid-phase procedures and purified to near homogeneity. CD, nmr, and modeling analysis indicated that in aqueous media the first extracellular loop peptide E1