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The XRCC1 399 glutamine allele is a risk factor for adenocarcinoma of the lung

✍ Scribed by Kevin K Divine; Frank D Gilliland; Richard E Crowell; Christine A Stidley; Therese J Bocklage; Dennis L Cook; Steven A Belinsky


Book ID
117614419
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
81 KB
Volume
461
Category
Article
ISSN
0921-8777

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Rare HRAS1 alleles are a risk factor for
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## BACKGROUND. The highly polymorphic HRAS1 minisatellite locus, located 1 kilobase downstream from the H-ras1 gene, has been associated with increased susceptibility to a variety of cancers. Microsatellite instability (MI), another molecular abnormality observed in human neoplasms, most likely re