The X-ray crystal and molecular structure of 5′-bromo-5′-deoxythymidine

✍ Scribed by Jaroslaw Błaszczyk; Wiesław R. Majzner; Michał W. Wieczorek; Lucyna A. Wózniak

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 217 KB
• Volume: 9
• Category: Article
• ISSN: 1042-7163
• DOI: 10.1002/(sici)1098-1071(1998)9:6<591::aid-hc11>3.0.co;2-m

✦ Synopsis

5Ј-Bromo-5Ј-deoxythymidine (1) crystallizes with four molecules in a monoclinic unit cell of space group C2. The ribose ring adopts an envelope conformation, transient between and E 0 (O4Ј-exo), 1 T 0 with the C1Ј atom being in the flap position. In the crystal lattice, the molecules are connected by intermolecular one-dimensional chains of hydrogen bondings from the hydroxyl hydrogen H3Ј(O3Ј) to the carbonyl oxygen O4. The differences in conformation and a hydrogen-bonding system of 1 with comparison to the structure of thymidine are observed.