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The x cystine/glutamate antiporter (xCT) as a potential target for therapy of cancer: Yet another cytotoxic anticancer approach?

✍ Scribed by Nic E. Savaskan; Eric Hahnen; Ilker Y. Eyüpoglu

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 54 KB
Volume: 220
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.21795

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✦ Synopsis

Abstract

This article was published online on 4 May 2009. An error was subsequently identified. This notice is included in the online and print versions to indicate that both have been corrected 8 June 2009.

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## Abstract The x cystine/glutamate antiporter is a major plasma membrane transporter for the cellular uptake of cystine in exchange for intracellular glutamate. Its main functions in the body are mediation of cellular cystine uptake for synthesis of glutathione essential for cellular protection fr