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The Wittig–Horner reaction for the synthesis of neratinib

✍ Scribed by Ning Gu, Jiabin Yang, Peng Wang, Lushen Li, Yang Chen…

Book ID
120765769
Publisher
Springer Netherlands
Year
2012
Tongue
English
Weight
288 KB
Volume
39
Category
Article
ISSN
0922-6168

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## Abstract The all‐(__E__)‐configured tetrastilbenylmethanes **3a**−**e** and **5a**,**b** can be obtained by fourfold Wittig−Horner reactions. The tetrahedral arrangement of these compounds guarantees independent stilbenoid chromophores with a high chromophore density. Apart from (__E__)/(__Z__)