β Scribed by Brian K Declan
No coin nor oath required. For personal study only.
An immune response involves a sequence of celluar interactios among macrophages, T lymphocytes, and B lymphocytes. Our own studies have revealed that macrophages play an important role in the regulation of antigen presentation to T cells. We have shown that the antigen is fist taken into the macrophages by an active metabolic process involving micro but not macropinocytosis. Antigen bound to macrophages is then displayed on the surface membrane associated directly or indirectly with major histocomptibility complex gene products called Ia antigens. This association constitutes the basis of self versus nonself recognition. While antibodies against self (Ia) inhibit recognition of macrophage-associated antigen by T cells, antibodies against antigen do not.We postulate that macrophages "select" only limited regions of the antigen molecule to serve as appropriate determinants for eliciting clonal expansion of T cells and helper cell activity for antibody production.
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