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The weaver mutation changes the ion selectivity of the affected inwardly rectifying potassium channel GIRK2

✍ Scribed by Yanhe Tong; Jianjun Wei; Shengwen Zhang; Judith A. Strong; Stephen R. Dlouhy; M.E. Hodes; Bernardino Ghetti; Lei Yu

Book ID
115932576
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
536 KB
Volume
390
Category
Article
ISSN
0014-5793

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Mutation analysis of the inwardly rectif
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Genetic factors play a major role in the etiology of idiopathic generalized epilepsy. However, in most syndromes, especially the common ones, multiple genetic factors seem to be involved. Mutations in K + channel genes have previously found to be associated with epilepsy both in humans and in mice.