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The von Hippel-Lindau protein: a key player in oxygen homeostasis and matrix assembly

✍ Scribed by M.A. Esteban; S.J. Mandriota; P.H. Maxwell

Book ID: 116536003
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 261 KB
Volume: 1262
Category: Article
ISSN: 0531-5131
DOI: 10.1016/j.ics.2003.11.048

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## Abstract VHL is the causative gene for von Hippel‐Lindau disease and sporadic clear cell renal cancer. It has been shown that pVHL can suppress the expression of certain genes that are overexpressed in renal carcinomas. One such gene is that encoding the potent mitogen and chemoattractant, plate